Cell culture

Biotechnology is one of the most innovative fields of the current industrial development. The applications reach from bio fuel production to biopharmaceuticals. In common of all those is the need for specifically balanced cell culture media to raise the microorganisms or mammalian cells, which produce the desired bio-products.

Besides energy sources like sugar, the ingredients for cell culture media include essential amino acids, which the cells need for their optimal growth and metabolic function. Extremely sensitive mammalian cells, used in the production of biopharmaceuticals or monoclonal antibodies, have to be breeded in a contamination-free environment. Here the highly purified and microbiology controlled Rexim^® amino acids are the ingredients of choice.

Furthermore, glutamine containing dipeptides, which are available at Evonik, are offering two substantial benefits compared to the use of simple L-Glutamine:

1. The dipetide structure protects glutamine from hydrolysis to glutamic acid, which occurs very quickly in the aqueous cell culture media and
2. The dipetides allow very high concentrations of the nutrient, due to 16–fold increased solubility.

Our glutamine containing Rexim^® dipeptides are bioequivalent to free L-Glutamine and are meeting highest requirements of microbial and chemical purity.